IgG4 Antibodies and Immune Tolerance: What You Need to Know

The development of repeated exposure to the SARS-CoV-2 spike protein can lead to a class switch towards non-inflammatory, spike-specific IgG4 antibodies. This can result in reduced protection against the virus and may require booster shots to maintain immunity. IgG4 antibodies are a type of antibody that can develop in response to repeated exposure to a specific antigen, such as the SARS-CoV-2 spike protein.

While IgG4 antibodies can help to neutralize the virus, they can also lead to immune tolerance, which can reduce the effectiveness of the vaccine. It is important for individuals to monitor their IgG4 levels after receiving an mRNA vaccine to ensure that they are not developing immune tolerance to the virus.